Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway.

@article{Li2012TaurineAM,
  title={Taurine attenuates methamphetamine-induced autophagy and apoptosis in PC12 cells through mTOR signaling pathway.},
  author={Yan Li and Zhengtao Hu and Bo Chen and Q Lisa Bu and Wenjie Lu and Yi Deng and Ruiming Zhu and Xue Shao and Jing Hou and Jinxuan Zhao and Hongyu Li and Baolai Zhang and Yina Huang and Lei Lv and Ying-Lan Zhao and Xiaobo Cen},
  journal={Toxicology letters},
  year={2012},
  volume={215 1},
  pages={1-7}
}
Methamphetamine (METH), a commonly abused psychostimulant, has been shown to induce neuronal damage by causing reactive oxygen species (ROS) formation, apoptosis and autophagy. Taurine (2-aminoethanesulfonic acid) is involved in several physiological actions in the brain, including neuroprotection, osmoregulation and neurotransmission. In this study, we investigate the protective effect of taurine against METH-induced neurotoxicity in PC12 cells and the underlying mechanism. The results showed… CONTINUE READING
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