Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats.

@article{Hagar2006TaurineAH,
  title={Taurine attenuates hypertension and renal dysfunction induced by cyclosporine A in rats.},
  author={Hanan H. Hagar and Eman El Etter and Maha Arafa},
  journal={Clinical and experimental pharmacology & physiology},
  year={2006},
  volume={33 3},
  pages={
          189-96
        }
}
Cyclosporine A (CsA) is the first-line immunosuppressant used for the management of solid organ transplantation and autoimmune diseases. Nephrotoxicity is the major limitation of CsA use. Recent evidence suggests that reactive oxygen species (ROS) play an important role in mediating CsA-induced hypertension and nephrotoxicity. Taurine, the major intracellular free beta-amino acid, is known to be an endogenous anti-oxidant and membrane-stabilizing agent. The present study was designed to… CONTINUE READING

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