Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases.

@article{Suzuki2002TaurineAA,
  title={Taurine as a constituent of mitochondrial tRNAs: new insights into the functions of taurine and human mitochondrial diseases.},
  author={Takeo Suzuki and Tsutomu Suzuki and Takeshi Wada and Kazuhiko Saigo and Kimitsuna Watanabe},
  journal={The EMBO journal},
  year={2002},
  volume={21 23},
  pages={6581-9}
}
Taurine (2-aminoethanesulphonic acid), a naturally occurring, sulfur-containing amino acid, is found at high concentrations in mammalian plasma and tissues. Although taurine is involved in a variety of processes in humans, it has never been found as a component of a protein or a nucleic acid, and its precise biochemical functions are not fully understood. Here, we report the identification of two novel taurine-containing modified uridines (5-taurinomethyluridine and 5-taurinomethyl-2… CONTINUE READING
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This is the first reported evidence that taurine is a constituent of biological macromolecules , unveiling the prospect of obtaining new insights into the functions and subcellular localization of this abundant amino acid .
Since modification of these taurine - containing uridines has been found to be lacking in mutant mitochondrial tRNAs for Leu(UUR ) and Lys from pathogenic cells of the mitochondrial encephalomyopathies MELAS and MERRF , respectively , our findings will considerably deepen our understanding of the molecular pathogenesis of mitochondrial encephalomyopathic diseases .
Since modification of these taurine - containing uridines has been found to be lacking in mutant mitochondrial tRNAs for Leu(UUR ) and Lys from pathogenic cells of the mitochondrial encephalomyopathies MELAS and MERRF , respectively , our findings will considerably deepen our understanding of the molecular pathogenesis of mitochondrial encephalomyopathic diseases .
Since modification of these taurine - containing uridines has been found to be lacking in mutant mitochondrial tRNAs for Leu(UUR ) and Lys from pathogenic cells of the mitochondrial encephalomyopathies MELAS and MERRF , respectively , our findings will considerably deepen our understanding of the molecular pathogenesis of mitochondrial encephalomyopathic diseases .
Since modification of these taurine - containing uridines has been found to be lacking in mutant mitochondrial tRNAs for Leu(UUR ) and Lys from pathogenic cells of the mitochondrial encephalomyopathies MELAS and MERRF , respectively , our findings will considerably deepen our understanding of the molecular pathogenesis of mitochondrial encephalomyopathic diseases .
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