Taurine Boosts Cellular Uptake of Small d-Peptides for Enzyme-Instructed Intracellular Molecular Self-Assembly

@inproceedings{Zhou2015TaurineBC,
  title={Taurine
Boosts Cellular Uptake of Small d-Peptides for Enzyme-Instructed
Intracellular Molecular Self-Assembly},
  author={Jie Zhou and Xuewen Du and Jie Li and Natsuko Yamagata and Bing Xu},
  booktitle={Journal of the American Chemical Society},
  year={2015}
}
Due to their biostability, D-peptides are emerging as an important molecular platform for biomedical applications. Being proteolytically resistant, D-peptides lack interactions with endogenous transporters and hardly enter cells. Here we show that taurine, a natural amino acid, drastically boosts the cellular uptake of small D-peptides in mammalian cells by >10-fold, from 118 μM (without conjugating taurine) to >1.6 mM (after conjugating taurine). The uptake of a large amount of the ester… CONTINUE READING

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