Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.

  title={Tau stabilizes microtubules by binding at the interface between tubulin heterodimers.},
  author={Harindranath Kadavath and Romina V. Hofele and Jacek Biernat and Satish Kumar and Katharina Tepper and Henning Urlaub and Eckhard Mandelkow and Markus Zweckstetter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 24},
The structure, dynamic behavior, and spatial organization of microtubules are regulated by microtubule-associated proteins. An important microtubule-associated protein is the protein Tau, because its microtubule interaction is impaired in the course of Alzheimer's disease and several other neurodegenerative diseases. Here, we show that Tau binds to microtubules by using small groups of evolutionary conserved residues. The binding sites are formed by residues that are essential for the… CONTINUE READING
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