Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β

@inproceedings{Vossel2015TauRP,
  title={Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β},
  author={Keith A. Vossel and Jordan C Xu and Vira Fomenko and Takashi Miyamoto and Elsa Suberbielle and Joseph A. Knox and Kaitlyn O. Ho and Daniel H. Kim and G. Yu and Lennart Mucke},
  booktitle={The Journal of cell biology},
  year={2015}
}
Axonal transport deficits in Alzheimer's disease (AD) are attributed to amyloid β (Aβ) peptides and pathological forms of the microtubule-associated protein tau. Genetic ablation of tau prevents neuronal overexcitation and axonal transport deficits caused by recombinant Aβ oligomers. Relevance of these findings to naturally secreted Aβ and mechanisms underlying tau's enabling effect are unknown. Here we demonstrate deficits in anterograde axonal transport of mitochondria in primary neurons from… CONTINUE READING
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