Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly.

Abstract

Recently exonic and intronic mutations in the gene for microtubule-associated protein tau have been discovered in cases of familial frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17). Intronic mutations have been shown to lead to an abnormal preponderance of four-repeat tau isoforms. The effects of the exonic mutations are unknown. We report here that the G272V, P301L, V337M and R406W mutations lead to a marked reduction in the ability of tau to promote microtubule assembly. This partial loss-of-function may be the primary effect of the known missense mutations in tau.

0200400600'99'01'03'05'07'09'11'13'15'17
Citations per Year

5,874 Citations

Semantic Scholar estimates that this publication has 5,874 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Hasegawa1998TauPW, title={Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly.}, author={Masatoshi Hasegawa and Michael J. Smith and Michel Goedert}, journal={FEBS letters}, year={1998}, volume={437 3}, pages={207-10} }