Tau protein liquid–liquid phase separation can initiate tau aggregation

  title={Tau protein liquid–liquid phase separation can initiate tau aggregation},
  author={Susanne Wegmann and Bahareh Eftekharzadeh and Katharina Tepper and Katarzyna Marta Zoltowska and Rachel E. Bennett and Simon Dujardin and Pawel R Laskowski and Danny MacKenzie and Tarun Kamath and Caitlin Commins and Charles Vanderburg and Allyson D. Roe and Zhanyun Fan and Amandine M Molliex and Amayra Hern{\'a}ndez-Vega and Daniel J. Muller and Anthony A. Hyman and Eckhard Mandelkow and J. Paul Taylor and Bradley T. Hyman},
  booktitle={The EMBO journal},
The transition between soluble intrinsically disordered tau protein and aggregated tau in neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau species can undergo liquid-liquid phase separation (LLPS) under cellular conditions and that phase-separated tau droplets can serve as an intermediate toward tau aggregate formation. We demonstrate that phosphorylated or mutant aggregation prone recombinant tau undergoes LLPS, as does high molecular weight soluble… CONTINUE READING

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