Tau protein and tau aggregation inhibitors

@article{Bulic2010TauPA,
  title={Tau protein and tau aggregation inhibitors},
  author={Bruno Bulic and Marcus Pickhardt and Eva-Maria Mandelkow and Eckhard Mandelkow},
  journal={Neuropharmacology},
  year={2010},
  volume={59},
  pages={276-289}
}
Alzheimer disease is characterized by pathological aggregation of two proteins, tau and Abeta-amyloid, both of which are considered to be toxic to neurons. In this review we summarize recent advances on small molecule inhibitors of protein aggregation with emphasis on tau, with activities mediated by the direct interference of self-assembly. The inhibitors can be clustered in several compound classes according to their chemical structure, with subsequent description of the structure-activity… CONTINUE READING
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