Tau protein: relevance to Parkinson's disease.

  title={Tau protein: relevance to Parkinson's disease.},
  author={Peng Lei and Scott Ayton and David Isaac Finkelstein and Paul A. Adlard and Colin L. Masters and Ashley I. Bush},
  journal={The international journal of biochemistry & cell biology},
  volume={42 11},
Tau is a microtubule-associated protein linked with neurodegenerative diseases. Humans express six different isoforms of tau; the longest containing four microtubule-binding repeat motifs in the C-terminal that are vital for what is considered the major biological function of tau, to stabilize microtubules and facilitate axonal transport. The capacity of tau to maintain its normal biological function is dependent upon its phosphorylation state. In Alzheimer's and Parkinson's diseases, there is… CONTINUE READING
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