Tau positron emission tomographic imaging in aging and early Alzheimer disease.

  title={Tau positron emission tomographic imaging in aging and early Alzheimer disease.},
  author={Keith A. Johnson and Aaron P. Schultz and Rebecca A. Betensky and J. Alex Becker and Jorge Sepulcre and Dorene M. Rentz and Elizabeth C. Mormino and Jasmeer P. Chhatwal and Rebecca E. Amariglio and Kate V Papp and Gad A. Marshall and Mark W Albers and Samantha A Mauro and Lesley C. Pepin and Jonathan Alverio and Kelly A Judge and Marlie Philiossaint and Timothy M. Shoup and Daniel L Yokell and Bradford C. Dickerson and Teresa G{\'o}mez-Isla and Bradley T. Hyman and Neil Vasdev and Reisa A. Sperling},
  journal={Annals of neurology},
  volume={79 1},
OBJECTIVE Detection of focal brain tau deposition during life could greatly facilitate accurate diagnosis of Alzheimer disease (AD), staging and monitoring of disease progression, and development of disease-modifying therapies. METHODS We acquired tau positron emission tomography (PET) using (18)F T807 (AV1451), and amyloid-β PET using (11)C Pittsburgh compound B (PiB) in older clinically normal individuals, and symptomatic patients with mild cognitive impairment or mild AD dementia… CONTINUE READING
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