Tau mutations in neurodegenerative diseases.

@article{Wolfe2009TauMI,
  title={Tau mutations in neurodegenerative diseases.},
  author={Michael S Wolfe},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 10},
  pages={6021-5}
}
Tau deposition is found in a variety of neurodegenerative brain diseases. The identification of tau mutations that cause familial dementia demonstrated that aberrant Tau alone could cause neurodegenerative disease and suggested that Tau likely plays a role in other cases in which Tau deposits are found, most notably Alzheimer disease. The mechanisms by which tau mutations cause neurodegeneration vary and are unclear to some degree, but evidence supports changes in alternative splicing… CONTINUE READING
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