Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum.

  title={Tau is central in the genetic Alzheimer-frontotemporal dementia spectrum.},
  author={Bart Dermaut and Samir Kumar-Singh and Rosa Rademakers and Jessie Theuns and Marc Cruts and Christine van Broeckhoven},
  journal={Trends in genetics : TIG},
  volume={21 12},
In contrast to the common and genetically complex senile form of Alzheimer's disease (AD), the molecular genetic dissection of inherited presenile dementias has given important mechanistic insights into the pathogenesis of degenerative brain disease. Here, we focus on recent genotype-phenotype correlative studies in presenile AD and the frontotemporal dementia (FTD) complex of disorders. Together, these studies suggest that AD and FTD are linked in a genetic spectrum of presenile degenerative… CONTINUE READING
20 Citations
87 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 20 extracted citations


Publications referenced by this paper.
Showing 1-10 of 87 references

Mutations in the endosomal ESCRTIIIcomplex subunit CHMP2B in frontotemporal dementia

  • G Skibinski
  • Nat. Genet
  • 2005

Presenilins mediate PI3K/Akt and ERK activation via select signaling receptors: selectivity of PS2 in PDGF signaling

  • Kang, D.E
  • J. Biol. Chem.,
  • 2005

Similar Papers

Loading similar papers…