Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo

@inproceedings{Wang2016TauIM,
  title={Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo},
  author={Peng Wang and G{\'e}rard Joberty and Arjan Buist and Alexandre Vanoosthuyse and Ilie-Cosmin Stancu and Bruno Vasconcelos and Nathalie Pierrot and Maria Faelth-Savitski and Pascal Kienlen-Campard and J. N. Octave and Marcus Bantscheff and Gerard Drewes and Diederik W. Moechars and Ilse Dewachter},
  booktitle={Acta Neuropathologica},
  year={2016}
}
Dysregulated proteostasis is a key feature of a variety of neurodegenerative disorders. In Alzheimer’s disease (AD), progression of symptoms closely correlates with spatiotemporal progression of Tau aggregation, with “early” oligomeric Tau forms rather than mature neurofibrillary tangles (NFTs) considered to be pathogenetic culprits. The ubiquitin–proteasome system (UPS) controls degradation of soluble normal and abnormally folded cytosolic proteins. The UPS is affected in AD and is identified… CONTINUE READING
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