Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.

@article{Shemesh2008TauinducedTJ,
  title={Tau-induced traffic jams reflect organelles accumulation at points of microtubule polar mismatching.},
  author={Or A Shemesh and Hadas Erez and Irith Ginzburg and Micha E. Spira},
  journal={Traffic},
  year={2008},
  volume={9 4},
  pages={458-71}
}
It is currently accepted that tau overexpression leads to impaired organelle transport and thus to neuronal degeneration. Nevertheless, the underlying mechanisms that lead to impaired organelle transport are not entirely clear. Using cultured Aplysia neurons and online confocal imaging of human tau, microtubules (MTs), the plus-end tracking protein - end-binding protein 3, retrogradely and anterogradely transported organelles, we found that overexpression of tau generates the hallmarks of human… CONTINUE READING

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