Tau-induced neurodegeneration: mechanisms and targets

@article{Beharry2013TauinducedNM,
  title={Tau-induced neurodegeneration: mechanisms and targets},
  author={Cindy Beharry and Leah S. Cohen and Jing Di and Kawsar Ibrahim and Susan Briffa-Mirabella and Alejandra del Carmen Alonso},
  journal={Neuroscience Bulletin},
  year={2013},
  volume={30},
  pages={346-358}
}
The accumulation of hyperphosphorylated tau is a common feature of several dementias. Tau is one of the brain microtubule-associated proteins. Here we discuss tau’s functions in microtubule assembly and stabilization and with regard to its interactions with other proteins. We describe and analyze important post-translational modifications: hyperphosphorylation, ubiquitination, glycation, glycosylation, nitration, polyamination, proteolysis, acetylation, and methylation. We discuss how these… CONTINUE READING

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