Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.

@article{Gratuze2015TauHA,
  title={Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.},
  author={Maud Gratuze and Anastasia No{\"e}l and Carl Julien and Giulia Cisbani and Philippe Milot-Rousseau and Françoise Morin and Maya F Dickler and Claudia Goupil and François Bezeau and Isabelle Poitras and St{\'e}phanie Bissonnette and Robert A. Whittington and S{\'e}bastien S. H{\'e}bert and Francesca Cicchetti and J Alexander Parker and Pershia Samadi and Emmanuel Planel},
  journal={Human molecular genetics},
  year={2015},
  volume={24 1},
  pages={86-99}
}
Huntington's disease (HD) is an autosomal-dominant neurodegenerative disorder caused by polyglutamine expansions in the amino-terminal region of the huntingtin (Htt) protein. At the cellular level, neuronal death is accompanied by the proteolytic cleavage, misfolding and aggregation of huntingtin. Abnormal hyperphosphorylation of tau protein is a characteristic feature of a class of neurodegenerative diseases called tauopathies. As a number of studies have reported tau pathology in HD patients… CONTINUE READING