Tau haplotypes regulate transcription and are associated with Parkinson's disease.

@article{Kwok2004TauHR,
  title={Tau haplotypes regulate transcription and are associated with Parkinson's disease.},
  author={John B. J. Kwok and Erdahl T. Teber and Clement T. Loy and Marianne Hallupp and G. E. Nicholson and George Mellick and Daniel D Buchanan and P. A. Silburn and Peter R. Schofield},
  journal={Annals of neurology},
  year={2004},
  volume={55 3},
  pages={329-34}
}
A primary haplotype (H1) of the microtubule-associated protein Tau (MAPT) gene is associated with Parkinson's disease (PD). However, the mechanism for disease susceptibility remains unknown. We examined the promoter region of MAPT and identified single nucleotide polymorphisms and insertions of 1 to 11 nucleotides. These polymorphisms corresponded to the previously characterized haplotypes, H1 and H2, as well as a novel variant of the H1 haplotype, H1'. As observed in other studies, we… CONTINUE READING

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