Tau complexes with phospholipase C-gamma in situ.

  title={Tau complexes with phospholipase C-gamma in situ.},
  author={Sarah Jenkins and Gail V W Johnson},
  volume={9 1},
Based on the results of recent in vitro studies, tau has been proposed to be involved in regulating signal transduction through the phospholipase C-gamma (PLC-gamma) signaling pathway. The present study provides support for the physiological relevance of this hypothesis by demonstrating the existence of a tau-PLC-gamma complex in situ in a human neuroblastoma cell line. Both PLC-gamma and PLC-delta, but not PLC-beta, co-purified with microtubule-associated proteins. PLC-gamma, but neither PLC… CONTINUE READING

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