Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs.

@article{Attems2007TauAA,
  title={Tau and alpha-synuclein brainstem pathology in Alzheimer disease: relation with extrapyramidal signs.},
  author={Johannes Attems and Magdalena Quass and Kurt A. Jellinger},
  journal={Acta neuropathologica},
  year={2007},
  volume={113 1},
  pages={53-62}
}
Extrapyramidal symptoms (EPS) in Alzheimer disease (AD) often increase with disease severity. Their neuropathological substrate is a matter of discussion. We investigated tau and alpha-synuclein (AS) pathologies in brainstem in AD patients with and without EPS. Among 160 elderly subjects with autopsy-proven AD (110 female, 50 male, aged 61-102, mean 84.1 +/- 8.3 SD years), 151 (94.4%) being demented, 35 (21.9%) had clinically reported EPS (rigidity, bradykinesia, gait impairment… CONTINUE READING
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