Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease

  title={Tau and Aβ imaging, CSF measures, and cognition in Alzheimer's disease},
  author={Matthew R. Brier and Brian Gordon and Karl Friedrichsen and John McCarthy and Ari Stern and Jon J. Christensen and Christopher Lloyd Owen and Patricia Aldea and Yi Su and Jason Hassenstab and Nigel J. Cairns and David M Holtzman and Anne M. Fagan and John C. Morris and Tammie L. Benzinger and Beau M. Ances},
  booktitle={Science Translational Medicine},
Alzheimer’s disease (AD) is characterized by two molecular pathologies: cerebral β-amyloidosis in the form of β-amyloid (Aβ) plaques and tauopathy in the form of neurofibrillary tangles, neuritic plaques, and neuropil threads. Until recently, only Aβ could be studied in humans using positron emission tomography (PET) imaging owing to a lack of tau PET imaging agents. Clinical pathological studies have linked tau pathology closely to the onset and progression of cognitive symptoms in patients… CONTINUE READING

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Current version and scoring rules

  • J. C. Morris, The Clinical Dementia Rating CDR
  • Neurology 43, 2412–2414
  • 1993
Highly Influential
4 Excerpts

Domi - nantly Inherited Alzheimer Network , Partial volume correction in quantitative amyloid imag

  • R. A. Sperling, P. S. Aisen, +18 authors C. H. Phelps
  • Neuroimage
  • 2015

Time, space and ‘wingmen

  • E. S. Musiek, D. M. Holtzman, Three dimensions of the amyloid hypothesis
  • Nat. Neurosci. 18, 800–806
  • 2015
1 Excerpt

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