Tau affects P53 function and cell fate during the DNA damage response

  title={Tau affects P53 function and cell fate during the DNA damage response},
  author={Martin E. Garcia Sola and Claudia Magrin and Giona Pedrioli and Sandra Pinton and Agnese Salvad{\`e} and Stéphanie Papin and Paolo Paganetti},
  journal={Communications Biology},
Cells are constantly exposed to DNA damaging insults. To protect the organism, cells developed a complex molecular response coordinated by P53, the master regulator of DNA repair, cell division and cell fate. DNA damage accumulation and abnormal cell fate decision may represent a pathomechanism shared by aging-associated disorders such as cancer and neurodegeneration. Here, we examined this hypothesis in the context of tauopathies, a neurodegenerative disorder group characterized by Tau protein… 

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  • Bidur PaudelSi-Yeon Jeong Marcus E. Peter
  • Biology
  • 2023
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