Tau Proteins and Neurofibrillary Degeneration

@article{Goedert1991TauPA,
  title={Tau Proteins and Neurofibrillary Degeneration},
  author={M. Goedert and M. Spillantini and R. Crowther},
  journal={Brain Pathology},
  year={1991},
  volume={1}
}
The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule‐associated protein tau forms an important, if not the sole, constituent of the paired helical filament. Tau protein in normal brain is bound to axonal microtubules by a tandem repeat region. In Alzheimer's disease a proportion of tau protein becomes abnormally phos‐phorylated and is no longer associated with… Expand
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