Tau Proteins and Neurofibrillary Degeneration

@article{Goedert1991TauPA,
  title={Tau Proteins and Neurofibrillary Degeneration},
  author={Michel Goedert and Maria Grazia Spillantini and R. Anthony Crowther},
  journal={Brain Pathology},
  year={1991},
  volume={1}
}
The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule‐associated protein tau forms an important, if not the sole, constituent of the paired helical filament. Tau protein in normal brain is bound to axonal microtubules by a tandem repeat region. In Alzheimer's disease a proportion of tau protein becomes abnormally phos‐phorylated and is no longer associated with… 
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  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
It is reported herein thatPHFs and SFs form hybrid filaments displaying both morphologies, that PHFs andSFs share surface epitopes, and that computed maps reveal a similar C-shaped morphological unit in PHFsand SFs, though differing in relative arrangement in the two types of filament.
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