Tau Proteins and Neurofibrillary Degeneration

@article{Goedert1991TauPA,
  title={Tau Proteins and Neurofibrillary Degeneration},
  author={M. Goedert and M. Spillantini and R. Crowther},
  journal={Brain Pathology},
  year={1991},
  volume={1}
}
The paired helical filament is the major fibrous component of neurofibrillary pathology in Alzheimer's disease. Over the last three years evidence has accumulated that the microtubule‐associated protein tau forms an important, if not the sole, constituent of the paired helical filament. Tau protein in normal brain is bound to axonal microtubules by a tandem repeat region. In Alzheimer's disease a proportion of tau protein becomes abnormally phos‐phorylated and is no longer associated with… Expand
162 Citations
Tau protein and the neurofibrillary pathology of Alzheimer's disease
  • M. Goedert
  • Biology, Medicine
  • Trends in Neurosciences
  • 1993
  • 621
Filamentous Tau Pathology in Nerve Cells, Astrocytes, and Oligodendrocytes of Aged Baboons
  • 73
  • PDF
Evolution of the neuropathology of Alzheimer's disease
  • H. Braak, E. Braak
  • Biology, Medicine
  • Acta neurologica Scandinavica. Supplementum
  • 1996
  • 606
NPT088 reduces both amyloid-β and tau pathologies in transgenic mice
  • 18
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 58 REFERENCES
The microtubule binding domain of tau protein
  • 426
Structural aspects of pathology in Alzheimer's disease.
  • R. Crowther
  • Chemistry, Medicine
  • Biochimica et biophysica acta
  • 1990
  • 52
Tau antisera recognize neurofibrillary tangles in a range of neurodegenerative disorders
  • 106
Straight and paired helical filaments in Alzheimer disease have a common structural unit.
  • R. Crowther
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
  • 258
  • PDF
Image reconstruction of the Alzheimer paired helical filament.
  • 166
...
1
2
3
4
5
...