Tau Phosphorylation, Aggregation, and Cell Toxicity

  title={Tau Phosphorylation, Aggregation, and Cell Toxicity},
  author={Jes{\'u}s {\'A}vila and Ismael Santa-Mar{\'i}a and M Teresa P{\'e}rez and Felix Hernandez and F. Javier Moreno},
  journal={Journal of Biomedicine and Biotechnology},
  pages={1516 - 1526}
Protein aggregation takes place in many neurodegenerative disorders. However, there is a controversy about the possible toxicity of these protein aggregates. In this review, this controversy is discussed, focussing on the tau aggregation that takes place in those disorders known as tauopathies. 
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An alternative interpretation of the amyloid Abeta hypothesis with regard to the pathogenesis of Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 1 Excerpt

Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2005
View 1 Excerpt

Ectopic expression of Musashi-1 in Alzheimer disease and Pick disease.

Journal of neuropathology and experimental neurology • 2005
View 1 Excerpt

Increase in tau tyrosine phosphorylation correlates with the formation of tau aggregates.

Brain research. Molecular brain research • 2005
View 1 Excerpt

Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo.

Proceedings of the National Academy of Sciences of the United States of America • 2005
View 2 Excerpts

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