Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

@article{Obulesu2011TauMN,
  title={Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology},
  author={Magisetty Obulesu and R. -C. Venu and R. Somashekhar},
  journal={Neurochemical Research},
  year={2011},
  volume={36},
  pages={1329-1335}
}
Extracellular accumulations of Aβ, hyperphosphorylation of tau and intracellular neurofibrillary tangle formation have been the hallmarks of Alzheimer’s Disease (AD). Although tau and its phosphorylation play a pivotal role in the normal physiology yet its hyperphosphorylation has been a pathological manifestation in neurodegenerative disorders like AD. In this review physiology of tau, its phosphorylation, hyperphosphorylation with the intervention of various kinases, aggregation and formation… CONTINUE READING