Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.

@article{Nobuhara2017TauAT,
  title={Tau Antibody Targeting Pathological Species Blocks Neuronal Uptake and Interneuron Propagation of Tau in Vitro.},
  author={Chloe K. Nobuhara and Sarah L DeVos and Caitlin Commins and Susanne Wegmann and Benjamin D Moore and Allyson D. Roe and Isabel M. Costantino and Matthew P. Frosch and Rose Pitstick and George A. Carlson and C. Hock and Roger M. Nitsch and Fabio Montrasio and Jan Grimm and Anne E Cheung and Anthone W. Dunah and Marion Wittmann and Thierry Bussi{\`e}re and Paul H Weinreb and Bradley T. Hyman and Shuko Takeda},
  journal={The American journal of pathology},
  year={2017},
  volume={187 6},
  pages={1399-1412}
}
The clinical progression of Alzheimer disease (AD) is associated with the accumulation of tau neurofibrillary tangles, which may spread throughout the cortex by interneuronal tau transfer. If so, targeting extracellular tau species may slow the spreading of tau pathology and possibly cognitive decline. To identify suitable target epitopes, we tested the… CONTINUE READING