Tau‐associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype

  title={Tau‐associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype},
  author={Daniel J. Brat and Marla Gearing and Patricia T. Goldthwaite and Bruce H. Wainer and Peter C. Burger},
  journal={Neuropathology and Applied Neurobiology},
Ganglion cell tumours, including gangliogliomas and gangliocytomas, are low grade neoplasms with a mature neuronal component. Ganglion cells within these lesions occasionally exhibit neurodegenerative changes including neurofibrillary tangles (NFT) similar to those in Alzheimer's disease. The frequency and spectrum of degenerative pathology in these lesions have not been defined, nor has their relation to patient age or factors such as apolipoprotein E (ApoE) genotype that predispose to… 
Abnormal tau deposition in neurons, but not in glial cells in the cerebral tissue surrounding arteriovenous malformation
  • T. Kon, F. Mori, K. Wakabayashi
  • Biology, Medicine
    Neuropathology : official journal of the Japanese Society of Neuropathology
  • 2012
The present findings indicate that abnormal tau deposition can occur in neurons, but not in glial cells, of the affected cerebral cortex surrounding AVM.
An immunohistochemical finding in glioneuronal lesions associated with epilepsy: The appearance of nestin‐positive, CD34‐positive and tau‐accumulating cells
The assertion that increases in the numbers of these cells might contribute to promoting epilepsy is supported, as these immunopositive cells are valuable findings for the pathological identification of epileptogenic lesions.
Desmoplastic ganglioglioma with meningiomatous and myofibroblastic components presenting with epilepsy
The clinical history is that of an 18-year-old man who presented with epileptic seizures since the age of 12 years, the characteristic of which remained unchanged, suggesting the same lesion was the cause.
Enhanced expression of autophagy-related p62 without increased deposits of neurodegeneration-associated proteins in glioblastoma and surrounding tissue - An autopsy-based study.
Evaluated neurodegeneration-associated protein deposition and autophagy as well as microglial activation within and surrounding glioblastoma suggested a preexisting rather than a tumor-induced Neurodegenerative condition.
Review article Infantile tauopathies: Hemimegalencephaly; tuberous sclerosis complex; focal cortical dysplasia 2; ganglioglioma q
Four developmental disorders of the fetal and infant brain are presented, each of which exhibits up-regulation of tau, and Tauopathies must be considered in infantile neurological disease and no longer restricted to adult dementias.
Tau and TDP-43 proteinopathies: kindred pathologic cascades and genetic pleiotropy
A complex but enlightening paradigm has emerged, wherein both Tau and TDP-43 proteinopathies are linked to numerous overlapping upstream influences, and both are associated with multiple downstream pathologically- and clinically-defined deleterious effects.
The Amygdala as a Locus of Pathologic Misfolding in Neurodegenerative Diseases
Parts of amygdalar anatomy, connectivity, vasculature, and pathologic involvement in neurodegenerative diseases with supporting data from the University of Kentucky Alzheimer's Disease Center autopsy cohort are reviewed.
Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature
Evidence from many independent research centers strongly supports the existence of a specific disease, as defined by the presence of A&bgr; plaques and neurofibrillary tangles.


Neuronal cytoskeletal changes are an early consequence of repetitive head injury
It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition, and the distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements.
Meningio‐angiomatosis: A Report of Six Cases with Special Reference to the Occurrence of Neurofibrillary Tangles
Six cases of meningio-angiomatosis are reported, a disorder of the cerebral cortex of probable malformative origin frequently associated with neurofibromatosis and either asymptomatic or associated with a seizure disorder, and neurofibrillary tangles described in a variety of disorders are reported.
α-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation
The appearance of an α-synuclein-positive structure was not limited to neurodegenerative diseases, but could also be detected in neoplastic cells showing neuronal differentiation.
HYPOTHALAMIC GANGLIOCYTOMA: Selective Appearance of Neurofibrillary Changes, Granulovacuolar Degeneration, and Argentophilic Bodies
  • M. Kudo
  • Medicine, Biology
    Acta pathologica japonica
  • 1986
A hamartomatous gangliocytoma was observed in the hypothalamus of a 54‐year‐old woman and the ultrastructural features of the neuroflbrillary changes were similar to those observed in Alzheimer's disease.
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia
A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. These include subacute sclerosing panencephalitis, lead
Tau in Alzheimer's disease.
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.
Preliminary findings suggest that possession of an APOE epsilon4 allele may be associated with increased severity of chronic neurologic deficits in high-exposure boxers.
Ganglioglioma containing osseous tissue and neurofibrillary tangles.
A ganglioglioma involving the temporoparietal lobe in a 49-year-old patient displayed several unusual histopathologic features. A large central focus of osseous tissue that was found may have