Tau‐associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype

@article{Brat2001TauassociatedNI,
  title={Tau‐associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype},
  author={Daniel J. Brat and Marla Gearing and Patricia T. Goldthwaite and Bruce H. Wainer and Peter C. Burger},
  journal={Neuropathology and Applied Neurobiology},
  year={2001},
  volume={27}
}
Ganglion cell tumours, including gangliogliomas and gangliocytomas, are low grade neoplasms with a mature neuronal component. Ganglion cells within these lesions occasionally exhibit neurodegenerative changes including neurofibrillary tangles (NFT) similar to those in Alzheimer's disease. The frequency and spectrum of degenerative pathology in these lesions have not been defined, nor has their relation to patient age or factors such as apolipoprotein E (ApoE) genotype that predispose to… 
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References

SHOWING 1-10 OF 42 REFERENCES
Neuronal cytoskeletal changes are an early consequence of repetitive head injury
TLDR
It appears that repetitive head injury in young adults is initially associated with neocortical NFT formation in the absence of Aβ deposition, and the distribution of the tau pathology suggests that the pathogenesis of cytoskeletal abnormalities may involve damage to blood vessels or perivascular elements.
Meningio‐angiomatosis: A Report of Six Cases with Special Reference to the Occurrence of Neurofibrillary Tangles
TLDR
Six cases of meningio-angiomatosis are reported, a disorder of the cerebral cortex of probable malformative origin frequently associated with neurofibromatosis and either asymptomatic or associated with a seizure disorder, and neurofibrillary tangles described in a variety of disorders are reported.
α-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation
TLDR
The appearance of an α-synuclein-positive structure was not limited to neurodegenerative diseases, but could also be detected in neoplastic cells showing neuronal differentiation.
HYPOTHALAMIC GANGLIOCYTOMA: Selective Appearance of Neurofibrillary Changes, Granulovacuolar Degeneration, and Argentophilic Bodies
  • M. Kudo
  • Medicine, Biology
    Acta pathologica japonica
  • 1986
TLDR
A hamartomatous gangliocytoma was observed in the hypothalamus of a 54‐year‐old woman and the ultrastructural features of the neuroflbrillary changes were similar to those observed in Alzheimer's disease.
Alzheimer neurofibrillary tangles in diseases other than senile and presenile dementia
A brief description is given of neurofibrillary changes of the paired helical filament type in a variety of chronic neurological diseases. These include subacute sclerosing panencephalitis, lead
Tau in Alzheimer's disease.
Apolipoprotein E epsilon4 associated with chronic traumatic brain injury in boxing.
TLDR
Preliminary findings suggest that possession of an APOE epsilon4 allele may be associated with increased severity of chronic neurologic deficits in high-exposure boxers.
Ganglioglioma containing osseous tissue and neurofibrillary tangles.
A ganglioglioma involving the temporoparietal lobe in a 49-year-old patient displayed several unusual histopathologic features. A large central focus of osseous tissue that was found may have
...
...