Tat protein of HIV-1 stimulates growth of cells derived from Kaposi's sarcoma lesions of AIDS patients

KAPOSI'S sarcoma (KS) is frequently associated with human immunodeficiency virus-1 (HIV-1) infection1. Supernatants from HIV-1-infected T cells carrying the CD4 antigen promote the growth of cells derived from KS lesions of AIDS patients (AIDS-KS cells)2, and the HIV-1 tat gene, introduced into the germ line of mice, induces skin lesions closely resembling… (More)