Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1.

@article{Mitola1997TathumanIV,
  title={Tat-human immunodeficiency virus-1 induces human monocyte chemotaxis by activation of vascular endothelial growth factor receptor-1.},
  author={Stefania Mitola and Silvano Sozzani and Walter Luini and Luca Primo and Alessandro Borsatti and Herbert A. Weich and Federico Bussolino},
  journal={Blood},
  year={1997},
  volume={90 4},
  pages={
          1365-72
        }
}
Human immunodeficiency virus-1 (HIV-1) Tat protein can be released by infected cells and activates mesenchymal cells. Among these, monocytes respond to Tat by migrating into tissues and releasing inflammatory mediators. In the present study, we have examined the molecular mechanism of monocyte activation by Tat, showing that this viral protein signals inside the cells through the tyrosine kinase receptor for vascular endothelial growth factor encoded by fms-like tyrosine kinase gene (VEGFR-1… CONTINUE READING

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