Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.

@article{Yedavalli2003TatAT,
  title={Tat and trans-activation-responsive (TAR) RNA-independent induction of HIV-1 long terminal repeat by human and murine cyclin T1 requires Sp1.},
  author={Venkat S. R. K. Yedavalli and Monsef Benkirane and K T Jeang},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 8},
  pages={6404-10}
}
P-TEFb, cyclin T1 + CDK9, is needed for the expression of cellular promoters and primate lentiviral long terminal repeats (LTRs). Curiously, cellular and lentiviral promoters differ dramatically in the requirements for positive transcriptional elongation factor (P-TEF) b activity. Lentiviral LTRs, but not cellular promoters, need an RNA-associated P-TEFb… CONTINUE READING