Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.

@article{Ott2004TatAA,
  title={Tat acetylation: a regulatory switch between early and late phases in HIV transcription elongation.},
  author={Melanie Ott and Alexander P. Dorr and Claudia Hetzer-Egger and Katrin Kaehlcke and Martina Schnolzer and Peter Henklein and Phil Cole and Ming-ming Zhou and Eric Verdin},
  journal={Novartis Foundation symposium},
  year={2004},
  volume={259},
  pages={182-93; discussion 193-6, 223-5}
}
The HIV transcriptional activator Tat enhances the processivity of RNA polymerase II by recruiting the CyclinT1/CDK9 complex to the TAR RNA element. In addition, Tat synergizes with the histone acetyltransferase p300 and is acetylated by p300 at a single lysine residue (K50) in the TAR RNA binding domain. We have recently reported that this post-translational modification is necessary for the interaction and transcriptional synergy of Tat with the transcriptional coactivator PCAF. We have… CONTINUE READING