Tat, Tat-associated kinase, and transcription.

  title={Tat, Tat-associated kinase, and transcription.},
  author={K T Jeang},
  journal={Journal of biomedical science},
  volume={5 1},
  • K T Jeang
  • Published 1998 in Journal of biomedical science
The HIV-1 Tat protein is an RNA-binding transcriptional transactivator. Recent findings suggest that Tat associates with a cellular kinase that phosphorylates the carboxyl-terminal domain of the largest subunit of RNA polymerase II. Here we review, in brief, the role of Tat-associated kinase in Tat-activated transcription. We discuss evidence that suggests involvement of TFIIH and/or P-TEFb. 

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