Taste responses to deuterium oxide

  title={Taste responses to deuterium oxide},
  author={Inglis J. Miller and Gregory Mooser},
  journal={Physiology \& Behavior},
2 Citations

Sweet taste of heavy water

The present multifaceted experimental study, complemented by homology modelling and molecular dynamics simulations, resolves a long-standing controversy about the taste of heavy water, shows that its sweet taste is mediated by the human TAS1R2/Tas1R3 taste receptor, and opens way to future studies of the detailed mechanism of action.



Membrane resistance change of the frog taste cells in response to water and Nacl

The electrical properties of the frog taste cells during gustatory stimulations with distilled water and varying concentrations of NaCl were studied with intracellular microelectrodes and it was concluded that the depolarizing responses of the NS and WS cells under the Ringer adaptation are produced by the permeability increase in some ions, mainly Na+ ions across the taste cell membranes.

Permeability of tongue epithelium and its relation to taste.

In general, tongue epithelium is as effective a barrier to chemical penetration as belly skin; the free endings of the lingual nerve are not readily accessible to chemicals.

NaCl thresholds in man: thresholds for water taste or NaCl taste?

  • L. Bartoshuk
  • Biology
    Journal of comparative and physiological psychology
  • 1974
These observations are important for behavior because saliva contains appreciable concentrations of Na and Cl ions: That is, saliva can act as an adapting solution and thereby alter NaCl thresholds.

The response of the frog's taste fibres to the application of pure water.

The physiological significance of the water effect upon the frog's tongue is discussed and it is suggested that it takes part in the regulatory mechanisms of the ionic balance.

The Basis of the Pharmacological Action of Heavy Water in Mammals *

  • H. Barbour
  • Chemistry
    The Yale journal of biology and medicine
  • 1937
Among all isotopes those which would be expected to show the greatest differences from the original element are the isotopes of hydrogen, for here the extra proton practically doubles the mass.


The treatment in this paper of available quantitative data on the response of taste receptors to sodium salt stimulation clearly indicates that the ions of the chemical stimulus are loosely bound to

Role of anions and cations in frog taste cell stimulation.

  • N. AkaikeM. Sato
  • Biology
    Comparative biochemistry and physiology. A, Comparative physiology
  • 1976

A Study of Taste and Smell of Heavy Water (99.8%) in Rats 1

  • C. P. Richter
  • Biology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1976
The low intensity of any untoward effects of heavy water and the faintness of its smell could explain the erratic variability of the reactions of rats to heavy water that put it in a different category from other substances tested so far.

The nature of taste receptor sites.