Taste receptor cells express pH-sensitive leak K+ channels.

  title={Taste receptor cells express pH-sensitive leak K+ channels.},
  author={Weihong Lin and Catherine A Burks and Dane R. Hansen and Sue C Kinnamon and Timothy A. Gilbertson},
  journal={Journal of neurophysiology},
  volume={92 5},
Two-pore domain K+ channels encoded by genes KCNK1-17 (K2p1-17) play important roles in regulating cell excitability. We report here that rat taste receptor cells (TRCs) highly express TASK-2 (KCNK5; K2p5.1), and to a much lesser extent TALK-1 (KCNK16; K2p16.1) and TASK-1 (KCNK3; K2p3.1), and suggest potentially important roles for these channels in setting resting membrane potentials and in sour taste transduction. Whole cell recordings of isolated TRCs show that a leak K+ (Kleak) current in a… CONTINUE READING
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