Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles.

@article{Sugao1998TasteMO,
  title={Taste masking of bitter drug powder without loss of bioavailability by heat treatment of wax-coated microparticles.},
  author={H Sugao and Shinji Yamazaki and Hiroyoshi Shiozawa and Koji Yano},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 1},
  pages={96-100}
}
Indeloxazine hydrochloride (IDX), a cerebral activator, has a bitter astringent taste. To prepare powders of IDX without this bitter taste, microparticles (median diameter, 130 microns) of IDX were coated with a mixture comprising hydrogenated oil and surfactants in a fluidized bed using the side-spray method. Drug release from the resulting coated particles was significantly delayed. Dissolution rate was remarkably enhanced, however, by heat-treating the coated particles at a temperature above… CONTINUE READING