Taste masked lipid pellets with enhanced release of hydrophobic active ingredient.

@article{Vaassen2012TasteML,
  title={Taste masked lipid pellets with enhanced release of hydrophobic active ingredient.},
  author={Jonathan Vaassen and Kathrin Bartscher and J{\"o}rg Breitkreutz},
  journal={International journal of pharmaceutics},
  year={2012},
  volume={429 1-2},
  pages={99-103}
}
Solid lipid extrusion is a suitable technique to produce oral dosage forms with improved taste properties. The design of a lipid formulation for poorly water soluble drugs is a challenge because of the poor dissolution and potential bioavailability problems. In this study, solid lipid extrusion at room temperature was applied for the formulation development of the BCS Class II drug NXP 1210. Powdered hard fat (Witocan(®) 42/44 mikrofein), glycerol distearate (Precirol(®) ato 5) and glycerol… CONTINUE READING

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