Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.

@article{Sukumaran2016TasteC,
  title={Taste cell-expressed α-glucosidase enzymes contribute to gustatory responses to disaccharides.},
  author={Sunil K Sukumaran and Karen K. Yee and Shusuke Iwata and Ramana Kotha and Roberto Quezada-Calvillo and Buford Lee Nichols and Sankar K Syracuse Mohan and Brian Mario Pinto and Noriatsu Shigemura and Yuzo Ninomiya and Robert F Margolskee},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 21},
  pages={
          6035-40
        }
}
The primary sweet sensor in mammalian taste cells for sugars and noncaloric sweeteners is the heteromeric combination of type 1 taste receptors 2 and 3 (T1R2+T1R3, encoded by Tas1r2 and Tas1r3 genes). However, in the absence of T1R2+T1R3 (e.g., in Tas1r3 KO mice), animals still respond to sugars, arguing for the presence of T1R-independent detection mechanism(s). Our previous findings that several glucose transporters (GLUTs), sodium glucose cotransporter 1 (SGLT1), and the ATP-gated K(+) (KATP… CONTINUE READING
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