Tastants evoke a cAMP signal in taste buds that is independent of calcium signaling

Abstract

We previously showed that rat taste buds express several adenylyl cyclases (ACs) of which, only AC8 is known to be stimulated by Ca 2+. Here, we demonstrate by direct measurements of cAMP levels, that AC activity in taste buds is stimulated by treatments that elevate intracellular Ca 2+. Specifically, 5 :M thapsigargin or 3 :M A23187 (calcium ionophore… (More)

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