Task-dependent development of cross-tolerance to psychomotor effects of lorazepam in man.

@article{Aranko1985TaskdependentDO,
  title={Task-dependent development of cross-tolerance to psychomotor effects of lorazepam in man.},
  author={Kari Aranko},
  journal={Acta pharmacologica et toxicologica},
  year={1985},
  volume={56 5},
  pages={
          373-81
        }
}
  • K. Aranko
  • Published 13 March 2009
  • Medicine, Psychology
  • Acta pharmacologica et toxicologica
Development of cross-tolerance between lorazepam and four other benzodiazepines (BZ) was studied in two trials by measuring objective psychomotor performance and by subjective assessments. In trial I, nitrazepam 10 mg (NZ), temazepam 20 mg (TZ) or placebo were administered to 14 healthy students for 10 consecutive nights. After each pretreatment, psychomotor impairment by the challenge dose of lorazepam 3 mg (LZ) was measured. In trial II, responses to LZ after pretreatment with diazepam 5 mg… 
14 Citations
Benzodiazepines, but not antidepressants or neuroleptics, induce dose‐dependent development of tolerance to lorazepam in psychiatric patients
TLDR
It is demonstrated that treatment with BZs induce dose‐dependent development of tolerance to psychomotor effects of lorazepam, and the initial learning effect in psychom motor performance was poorer among BZ users than among others.
The natural history of tolerance to the benzodiazepines.
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Ex-long-term benzodiazepine users are more likely to manifest two specific types of effects--immediate 'symptom' reduction and exacerbation of 'withdrawal symptoms' over the subsequent week following complete abstinence from the drug.
Chronic benzodiazepine administration
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Cross-tolerance to the convulsant effects of pentylenetetrazole between lorazepam and alprazolam is demonstrated, however, effects of the two compounds on benzodiazepine receptor binding in hippocampus remain distinct.
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No tolerance developed for the effect of flunitrazepam on free recall and the subjects' rating of attention and these effects had nearly equal time courses during the treatment period, which may indicate that the amnesic effect of benzodiazepines is at least partially mediated through the effects on attention or general arousal.
Chronic benzodiazepine administration
TLDR
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TLDR
The relationships between alprazolam and metabolite concentrations and CNS effects were determined in a double-blind placebo controlled four-way crossover trial in 16 normal male volunteers, suggesting a tolerance which was sustained during the 10-day washout between phases.
Benzodiazepine cross-tolerance in mice extends to sodium valproate.
Comparative study of the abuse liability of alprazolam, lorazepam, diazepam, methaqualone, and placebo.
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This double-blind, crossover trial tested 30 casual recreational sedative users in a seminaturalistic setting, finding that Methaqualone was more euphoriant and less sedative than the benzodiazepines.
The biological basis of benzodiazepine dependence.
TLDR
It is concluded that the same underlying mechanism mediates the rebound phenomena and tolerance seen after short-term or acute benzodiazepine administration, and also that tolerance is simply another manifestation of this same mechanism.
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TLDR
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