Tartrate-resistant acid phosphatase facilitates hydroxyl radical formation and colocalizes with phagocytosed Staphylococcus aureus in alveolar macrophages.

@article{Risnen2001TartrateresistantAP,
  title={Tartrate-resistant acid phosphatase facilitates hydroxyl radical formation and colocalizes with phagocytosed Staphylococcus aureus in alveolar macrophages.},
  author={Seija R R{\"a}is{\"a}nen and Jussi M. Halleen and Vilhelmiina Parikka and H. Kalervo V{\"a}{\"a}n{\"a}nen},
  journal={Biochemical and biophysical research communications},
  year={2001},
  volume={288 1},
  pages={142-50}
}
Tartrate-resistant acid phosphatase (TRAP) is an enzyme expressed specifically in osteoclasts and activated macrophages, two phagocytosing cell types originating from the same hematopoietic stem cells. TRAP contains a binuclear iron centre which has been shown to generate reactive oxygen species (ROS). In this study murine macrophage like cell line RAW-264 overexpressing TRAP was shown to produce elevated levels of hydroxyl radicals compared to parental cells. TRAP transfected cells also had… CONTINUE READING

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