Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment.

@article{Fiorucci2010TargettingFF,
  title={Targetting farnesoid-X-receptor: from medicinal chemistry to disease treatment.},
  author={Stefano Fiorucci and Andrea Mencarelli and Eleonora Distrutti and Giuseppe Palladino and Sabrina Cipriani},
  journal={Current medicinal chemistry},
  year={2010},
  volume={17 2},
  pages={
          139-59
        }
}
The farnesoid X receptor (FXRalpha) is a metabolic nuclear receptor and bile acid sensor expressed in the liver and intestine. Physiological studies have shown that FXRalpha exerts regulatory roles in bile acids, lipid and glucose homeostasis. FXR ligands of steroidal and non-steroidal structure have been described. Both ligand groups have shown limitations in preclinical studies regarding their absorption, metabolism, target interactions and intrinsic toxicity. Inhibition of bile acid… CONTINUE READING

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Nonacidic Farnesoid X Receptor Modulators.

Journal of medicinal chemistry • 2017

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