Targets of the cyclin-dependent kinase Cdk1

@article{Ubersax2003TargetsOT,
  title={Targets of the cyclin-dependent kinase Cdk1},
  author={Jeffrey A. Ubersax and Erika L. Woodbury and Phuong N. Quang and Maria T.Z. Paraz and Justin D. Blethrow and Kavita Shah and Kevan M. Shokat and David O. Morgan},
  journal={Nature},
  year={2003},
  volume={425},
  pages={859-864}
}
The events of cell reproduction are governed by oscillations in the activities of cyclin-dependent kinases (Cdks). Cdks control the cell cycle by catalysing the transfer of phosphate from ATP to specific protein substrates. Despite their importance in cell-cycle control, few Cdk substrates have been identified. Here, we screened a budding yeast proteomic library for proteins that are directly phosphorylated by Cdk1 in whole-cell extracts. We identified about 200 Cdk1 substrates, several of… Expand
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