Targets of statin therapy: LDL cholesterol, non-HDL cholesterol, and apolipoprotein B in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS).

@article{CharltonMenys2009TargetsOS,
  title={Targets of statin therapy: LDL cholesterol, non-HDL cholesterol, and apolipoprotein B in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS).},
  author={Valentine Charlton-Menys and David John Betteridge and Helen M. Colhoun and JohnH. Fuller and Michael France and Graham A. Hitman and Shona J. Livingstone and H. Andrew W. Neil and C. Benjamin Newman and Michael Szarek and David Demicco and PaulN. Durrington},
  journal={Clinical chemistry},
  year={2009},
  volume={55 3},
  pages={
          473-80
        }
}
BACKGROUND LDL can vary considerably in its cholesterol content; thus, lowering LDL cholesterol (LDLC) as a goal of statin treatment implies the existence of considerable variation in the extent to which statin treatment removes circulating LDL particles. This consideration is particularly applicable in diabetes mellitus, in which LDL is frequently depleted of cholesterol. METHODS Type 2 diabetes patients randomly allocated to 10 mg/day atorvastatin (n = 1154) or to placebo (n = 1196) for 1… CONTINUE READING

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