Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations

@article{PerezLopez2015TargetsOD,
  title={Targets of drugs are generally, and targets of drugs having side effects are specifically good spreaders of human interactome perturbations},
  author={{\'A}. R. Perez-Lopez and Kristof Z. Szalay and D. T{\"u}rei and D. M{\'o}dos and K. Lenti and T. Korcsm{\'a}ros and P. Csermely},
  journal={Scientific Reports},
  year={2015},
  volume={5}
}
Network-based methods are playing an increasingly important role in drug design. Our main question in this paper was whether the efficiency of drug target proteins to spread perturbations in the human interactome is larger if the binding drugs have side effects, as compared to those which have no reported side effects. Our results showed that in general, drug targets were better spreaders of perturbations than non-target proteins, and in particular, targets of drugs with side effects were also… Expand
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