Targets of balancing selection in the human genome.

@article{Andrs2009TargetsOB,
  title={Targets of balancing selection in the human genome.},
  author={Aida M. Andr{\'e}s and Melissa J. Hubisz and Amit R. Indap and Dara G. Torgerson and Jeremiah D. Degenhardt and Adam R. Boyko and Ryan N. Gutenkunst and Thomas J. White and Eric D. Green and Carlos Daniel Bustamante and Andrew G. Clark and Rasmus Nielsen},
  journal={Molecular biology and evolution},
  year={2009},
  volume={26 12},
  pages={2755-64}
}
Balancing selection is potentially an important biological force for maintaining advantageous genetic diversity in populations, including variation that is responsible for long-term adaptation to the environment. By serving as a means to maintain genetic variation, it may be particularly relevant to maintaining phenotypic variation in natural populations. Nevertheless, its prevalence and specific targets in the human genome remain largely unknown. We have analyzed the patterns of diversity and… CONTINUE READING