Targets of Vitamin D Receptor Signaling in the Mammary Gland

@article{Welsh2007TargetsOV,
  title={Targets of Vitamin D Receptor Signaling in the Mammary Gland},
  author={JoEllen Welsh},
  journal={Journal of Bone and Mineral Research},
  year={2007},
  volume={22}
}
  • J. Welsh
  • Published 1 December 2007
  • Biology, Medicine
  • Journal of Bone and Mineral Research
Since the discovery of the vitamin D receptor (VDR) in mammary cells, the role of the vitamin D signaling pathway in normal glandular function and in breast cancer has been extensively explored. In vitro studies have shown that the VDR ligand, 1,25‐dihydroxyvitamin D (1,25D), modulates key proteins involved in signaling proliferation, differentiation, and survival of normal mammary epithelial cells. Similar anti‐proliferative and pro‐differentiating effects of 1,25D have been observed in VDR… 

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It is demonstrated that knockdown of the VDR strongly increases the metastatic potential of MDA‐MB‐231 human breast cancer cells to bone, resulting in significantly greater skeletal tumor burden.
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