Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage.

@article{He2012TargetsAI,
  title={Targets and intracellular signaling mechanisms for deoxynivalenol-induced ribosomal RNA cleavage.},
  author={Kaiyu He and Hui-ren Zhou and James J. Pestka},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2012},
  volume={127 2},
  pages={382-90}
}
The trichothecene mycotoxin deoxynivalenol (DON), a known translational inhibitor, induces ribosomal RNA (rRNA) cleavage. Here, we characterized this process relative to (1) specific 18S and 28S ribosomal RNA cleavage sites and (2) identity of specific upstream signaling elements in this pathway. Capillary electrophoresis indicated that DON at concentrations as low as 200 ng/ml evoked selective rRNA cleavage after 6 h and that 1000 ng/ml caused cleavage within 2 h. Northern blot analysis… CONTINUE READING

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