Targets and dynamics of promoter DNA methylation during early mouse development

@article{Borgel2010TargetsAD,
  title={Targets and dynamics of promoter DNA methylation during early mouse development},
  author={Julie Borgel and S. Guibert and Yufeng Li and Hatsune Chiba and D. Sch{\"u}beler and H. Sasaki and T. Forn{\'e} and M. Weber},
  journal={Nature Genetics},
  year={2010},
  volume={42},
  pages={1093-1100}
}
DNA methylation is extensively reprogrammed during the early phases of mammalian development, yet genomic targets of this process are largely unknown. We optimized methylated DNA immunoprecipitation for low numbers of cells and profiled DNA methylation during early development of the mouse embryonic lineage in vivo. We observed a major epigenetic switch during implantation at the transition from the blastocyst to the postimplantation epiblast. During this period, DNA methylation is primarily… Expand
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