Targets and consequences of protein SUMOylation in neurons

  title={Targets and consequences of protein SUMOylation in neurons},
  author={K. A. Wilkinson and Y. Nakamura and J. Henley},
  journal={Brain Research Reviews},
  • K. A. Wilkinson, Y. Nakamura, J. Henley
  • Published 2010
  • Biology, Medicine
  • Brain Research Reviews
  • The post-translational modification of proteins is critical for the spatial and temporal regulation of signalling cascades. This is especially important in the CNS where the processes affecting differentiation, growth, targeting and communication between neurones are highly complex and very tightly regulated. In recent years it has emerged that modification of proteins by members of the SUMO (small ubiquitin-related modifier) family of proteins play key roles in neuronal function. SUMOylation… CONTINUE READING
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