Targeting xenobiotic receptors PXR and CAR for metabolic diseases.

  title={Targeting xenobiotic receptors PXR and CAR for metabolic diseases.},
  author={Jie Gao and Wen Xie},
  journal={Trends in pharmacological sciences},
  volume={33 10},
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are two closely related and liver-enriched nuclear hormone receptors originally defined as xenobiotic receptors. Recently, an increasing body of evidence suggests that PXR and CAR also have endobiotic functions that impact glucose and lipid metabolism, as well as the pathogenesis of metabolic diseases. These new findings suggest that PXR and CAR not only regulate the transcription of drug-metabolizing enzymes and… CONTINUE READING